
You are not alone
Primary immunodeficiency (PI) doesn’t have to feel isolating.
Primary immunodeficiency (PI) doesn’t have to feel isolating.
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Take our self-assessment to find out if your symptoms could point to a primary immunodeficiency (PI). It’s an informative way to gather insights that you can discuss with your healthcare provider.
Join us for a transformative experience where every story, voice, and journey creates something extraordinary.
A mosaic showcases the beauty of diversity and strength that arises from unique pieces coming together.
For this reason, the 2026 National Conference in San Antonio, TX features a mosaic theme, and this vibrant, dynamic event will blend individual primary immunodeficiency (PI) stories to form a unique whole.
Make a difference this year! Our 2025 season offers multiple ways to get involved. Form a team, join a team, walk individually, or donate. Click below to learn more and register.
"Compromised: Life Without Immunity" takes you inside the rarely-seen world of primary immunodeficiency. Through six powerful stories, discover how strength, support, and medical care make life possible despite seemingly impossible challenges. Join us for an upcoming screening or host your own.
When two of the internet's most engaging content creators—CDawgVA (Connor Colquhoun) and VTuber Ironmouse—came together to support the Immune Deficiency Foundation, something extraordinary happened. What began as a friendship between a charismatic streamer and a talented VTuber living with common variable immune deficiency (CVID) has grown into one of the most impactful partnerships in content creator fundraising.
If you are living with PI, think you might have PI, are a caregiver, a healthcare professional, or are just looking to learn more we can help.
website sessions linking the community to vital resources.
individuals turned to AskIDF to 1,910 PI-related questions.
individuals living with PI were supported and empowered.
*statistics based on 2024 Community Impact Report
The more we learn about plasma, the more we realize its life-saving potential. We need heroes to step up, donate, and save lives.
There are more than 450 primary immunodeficiencies, also known as inborn errors of immunity (IEI).
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Listen to the latest episode of the IDF Podcast, or one of our sub-series Undiagnosed or Bold Conversations.
Join IDF on YouTube to help spread awareness and education about PI and tune in to see what is happening.
Joining forces to protect the most vulnerable against infectious disease.
Learn more about all the ways to learn, connect, and engage with IDF, whether online and in person.
Browse the latest news articles, videos, and podcasts to find the most up-to-date information about advancements in PI treatments, portrayal in the media, and other IDF efforts.
Receive news and helpful resources to your cell phone or inbox. You can change or cancel your subscription at any time.